2,3-双(4-羟苯基)丙腈

生物活性靶点体外研究体内研究 2,3-双(4-羟苯基)丙腈试剂级价格

2,3-双(4-羟苯基)丙腈

CAS号:1428-67-7
英文名:2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE
中文名:2,3-双(4-羟苯基)丙腈
CBNumber:CB2379797
分子式:C15H13NO2
分子量:239.27
MOL File:1428-67-7.mol

2,3-双(4-羟苯基)丙腈化学性质

熔点 :200.0 to 204.0 °C
沸点 :449.4±35.0 °C(Predicted)
密度 :1.256±0.06 g/cm3(Predicted)
RTECS号 :UG0900000
储存条件 :-20°C
溶解度 :DMSO: soluble10mg/mL, clear
形态 :powder
酸度系数(pKa) :9.41±0.26(Predicted)
颜色 :white to beige
水溶解性 :Soluble in 1eq. NaOH (30 mM), ethanol (100 mM), DMSO (100 mM), DMF (~30 mg/ml), and water (0.5 mg/ml at 25°C).
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

安全信息

危险品标志 :Xi,N
危险类别码 :36-50
安全说明 :26-61
危险品运输编号 :UN 3077 9 / PGIII
WGK Germany :3
海关编码 :2926.90.4801
危险等级 :9

2,3-双(4-羟苯基)丙腈性质、用途与生产工艺

生物活性 DPN (Diarylpropionitrile) 是一种非甾体雌激素受体 ERβ 选择性配体，其 EC50 值为 0.85 nM。DPN 在许多神经系统疾病具有神经保护作用。
靶点

ERβ

0.85 nM (EC ₅₀ )
体外研究

DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC ₅₀ =0.85 nM for ERβ; EC ₅₀ =66 nM for ERα).
DPN (10 nM) prevents morphological alterations from Aβ _1-42 (10 μM)-induced toxicity in cultured cortical neurons.
DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner.
DPN (0.1-100 nM) significantly reduces Aβ _1-42 -stimulated expression of Bax in a non-dose dependent manner.
DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ _1-42 treatment on cultured cortical neurons.
DPN (0.1-100 nM) suppresses the Aβ _1-42 -upregulated phosphorylation of JNK and p38.

体内研究

DPN (10 μg; s.c.; daily; for 11 days) increases swimming and decreases immobility in the FST, and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model.

Animal Model:	Adult Sprague-Dawley female rats (220-250 g), ovariectomized animal models
Dosage:	10 μg/rat
Administration:	Subcutaneous injections, daily, for 11 days
Result:	Increased swimming and decreased immobility in the FST.