CPTH2
- CAS号:357649-93-5
- 英文名:Histone Acetyltransferase Inhibitor IV, CPTH2
- 中文名:CPTH2
- CBNumber:CB22602855
- 分子式:C14H14ClN3S
- 分子量:291.8
- MOL File:357649-93-5.mol
- 熔点 :190-191 °C
- 沸点 :460.3±37.0 °C(Predicted)
- 密度 :1.38±0.1 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :Soluble in DMSO
- 形态 :powder
- 酸度系数(pKa) :14.57±0.20(Predicted)
- 颜色 :white to beige
- 水溶解性 :Water: < 0.1 mg/mL (insoluble)
- 敏感性 :Light Sensitive
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- WGK Germany :nwg
CPTH2性质、用途与生产工艺
- 生物活性 CPTH2 是一种有效的 histone acetyltransferase (HAT) 的抑制剂，可调节Gcn5p网络。CPTH2 通过抑制 KAT3B 诱导凋亡并降低ccRCC细胞系的侵袭性。
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靶点
Target Value HAT
()Gcn5p
()KAT3B
() -
体外研究
CPTH2 (100 μM; 12, 24, 48 hours) causes a decrease in cell proliferation after as early as 12 h with a further significant reduction after 48 h stimulation.
CPTH2 (100 μM; 12 or 48 hours) causes a comparable drop of the activity in both cell lines.
CPTH2 (100 μM; 48 hours) produces a drastic increase in apoptotic/dead cell population after 48 h.
CPTH2 (100 μM; 12, 24, 48 hours) shows a reduced acetylation of both global AcH3 histone and H3AcK18.
CPTH2 (100 μM; 24, 48 hours) is capable to counteract invasion and migration of ccRCC-786-O cells in culture.
CPTH2 (0.2, 0.5, 1 mM) inhibits the growth of a GCN5 deleted strain and a single catalytic mutant E173H.
CPTH2 (0.6, 0.8 mM; for 24 hours) inhibits histone H3 acetylation in yeast cell cultures.
CPTH2 inhibits the Gcn5p dependent functional network.
Cell Proliferation Assay
Cell Line: Papillary thyroid (K1) and clear cell Renal Cell Carcinoma (ccRCC-786-O) cell lines Concentration: 100 μM Incubation Time: 12, 24, 48 hours Result: Caused a decrease in cell proliferation after as early as 12 h with a further significant reduction after 48 h stimulation. Cell Viability Assay
Cell Line: K1 and ccRCC-786-O cell lines Concentration: 100 μM Incubation Time: 24 hours (K1 cell) and 48 hours (ccRCC-786-O cell) Result: Caused a comparable drop of the activity in both cell lines. Apoptosis Analysis
Cell Line: ccRCC-786-O cells Concentration: 100 μM Incubation Time: 48 hours Result: Produced a drastic increase in apoptotic/dead cell population after 48 h. Western Blot Analysis
Cell Line: ccRCC-786-O cells Concentration: 100 μM Incubation Time: 12, 24, 48 hours Result: Showed a reduced acetylation of both global AcH3 histone and H3AcK18.
- 更新日期：2024/11/11
- 产品编号：XW35764993501
- 产品名称：试剂CPTH2 CPTH2
- CAS编号：
- 包装：25mg
- 价格：3410元
- 更新日期：2024/11/08
- 产品编号：HY-W013274
- 产品名称：CPTH2
- CAS编号：
- 包装：5 mg
- 价格：875元
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
