ChemicalBook CAS数据库列表 苦木素
苦木素
- CAS号:76-78-8
- 英文名:QUASSIN
- 中文名:苦木素
- CBNumber:CB2147903
- 分子式:C22H28O6
- 分子量:388.45
- MOL File:76-78-8.mol
苦木素化学性质
- 熔点 :222°
- 比旋光度 :D20 +34.5° (c = 5.09 in CHCl3)
- 沸点 :586.3±50.0 °C(Predicted)
- 密度 :1.23±0.1 g/cm3(Predicted)
- 储存条件 :-20°C Freezer, Under inert atmosphere
- 溶解度 :Chloroform (Slightly), Methanol (Slightly)
- 形态 :Solid
- 颜色 :White to Off-White
- 旋光性 (optical activity) :+34.520 (c 5.09, CHCl3)
- LogP :2.220 (est)
- EPA化学物质信息 :Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- (76-78-8)
苦木素性质、用途与生产工艺
- 生物活性 Quassin (Nigakilactone D) 是一种从 Quassia amara 的茎皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum，IC50 为 0.15 μM。Quassin 具有可逆的抗生育能力，抗雌激素和抗疟原虫活性。
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靶点
IC50: 0.15 μM ( P. falciparum )
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体外研究
Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion.
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体内研究
Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats.
Animal Model: 35 females albino rats (150-170 g) Dosage: 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg Administration: Oral administration; daily; for 60 days Result: There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats. - 用途 Quassin is a naturally occurring extract from quassia trees and is used in traditional chinese medicine for it鈥檚 antiulcerogenic properties. Quassin have also been used as an additive in soft drinks.
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苦木素 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-N1581
- 产品名称：苦木素 Quassin
- CAS编号：76-78-8
- 包装：1mg
- 价格：900元
- 更新日期：2024/11/08
- 产品编号：HY-N1581
- 产品名称：苦木素 Quassin
- CAS编号：76-78-8
- 包装：5mg
- 价格：3600元
苦木素生产厂家
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
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