ChemicalBook CAS数据库列表 苦参醇
苦参醇
- CAS号:855746-98-4
- 英文名:Kurarinol
- 中文名:苦参醇
- CBNumber:CB13037363
- 分子式:C26H32O7
- 分子量:456.53
- MOL File:855746-98-4.mol
苦参醇化学性质
- 熔点 :166-169 °C
- 沸点 :683.8±55.0 °C(Predicted)
- 密度 :1.250±0.06 g/cm3(Predicted)
- 溶解度 :Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- 形态 :Powder
- 酸度系数(pKa) :7.54±0.40(Predicted)
苦参醇性质、用途与生产工艺
- 生物活性 Kurarinol 是一种黄烷酮，在 Sophora flavescens 根中被发现。Kurarinol 是一种竞争性的酪氨酸酶 (tyrosinase) 抑制剂，对蘑菇型酪氨酸酶作用的 IC50 为 0.1 μM 。
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靶点
IC50: 0.1 μM (mushroom tyrosinase)
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体外研究
Kurarinol manifests relatively low cytotoxic activity (EC 50 >30 μM).
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism.
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3).
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体内研究
Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats.
Animal Model: Male Sprague-Dawley rats (120-130g), hypercholesterolemic models Dosage: 20 mg/kg Administration: Oral administration, daily, for 3 days Result: Decreased serum TC, TG, and LDL-C levels.
苦参醇上下游产品信息
上游原料
下游产品
苦参醇生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
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