D-鞘氨醇
- CAS号:123-78-4
- 英文名:D-ERYTHRO-SPHINGOSINE
- 中文名:D-鞘氨醇
- CBNumber:CB1262764
- 分子式:C18H37NO2
- 分子量:299.49
- MOL File:123-78-4.mol
- 熔点 :74.2-78.1 °C
- 沸点 :440.8°C (rough estimate)
- 密度 :0.9758 (rough estimate)
- 折射率 :1.5000 (estimate)
- 储存条件 :-20°C
- 溶解度 :chloroform: 20 mg/mL, clear, colorless to very faintly yellow
- 酸度系数(pKa) :11.80±0.45(Predicted)
- 形态 :Powder or Waxy Solid
- 颜色 :White to cream
- Merck :14,8747
- BRN :1727294
- 稳定性 :Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
- InChIKey :WWUZIQQURGPMPG-KRWOKUGFSA-N
- CAS 数据库 :123-78-4
D-鞘氨醇性质、用途与生产工艺
- 生物活性 鞘氨醇，Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine)，是具有不饱和烃链的18个碳原子的氨基醇，它形成鞘脂的主要部分，鞘脂是一类细胞膜脂质，其中包括鞘磷脂，一种重要的磷脂。
-
靶点
p32
8 μM (EC 50 )
PKC
PP2A
Human Endogenous Metabolite
-
体外研究
A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines. D-erythro-Sphingosine inhibits protein kinase C in vitro. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells.
- 更新日期：2024/11/08
- 产品编号：33153
- 产品名称：D-鞘氨醇 D-erythro-Sphingosine, 99+%, synthetical
- CAS编号：123-78-4
- 包装：50mg
- 价格：2356元
- 更新日期：2024/11/08
- 产品编号：33153
- 产品名称：D-鞘氨醇 D-erythro-Sphingosine, 99+%, synthetical
- CAS编号：123-78-4
- 包装：250mg
- 价格：6639元
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
