4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶

生物活性靶点体外研究体内研究 4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶试剂级价格

CAS号:193746-75-7
英文名:SB242235
中文名:4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶
CBNumber:CB12621150
分子式:C19H20FN5O
分子量:353.39
MOL File:193746-75-7.mol

4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶化学性质

沸点 :568.4±60.0 °C(Predicted)
密度 :1.34
储存条件 :2-8°C(protect from light)
溶解度 :DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml
形态 :Powder
酸度系数(pKa) :9.91±0.10(Predicted)
颜色 :White to off-white

安全信息

海关编码 :2924297099

4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶性质、用途与生产工艺

生物活性 SB-242235　是一种有效、选择性的　p38 MAP 激酶抑制剂，在人的软骨细胞中　IC50　值为 1.0 μM。
靶点

IC50: 1.0　μM (p38 MAPK, primary human chondrocytes)

体外研究

SB 242235 (0-10　μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC ₅₀ of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.

Western Blot Analysis

Cell Line:	Human chondrocytes
Concentration:	0 μM,0.01 μM,0.1 μM,1 μM,10　μM
Incubation Time:	15 minutes
Result:	Dose-dependently inhibited the activation of MAPKAP K2 with an IC ₅₀ of 1.0 μM.

体内研究

SB242235 (100 mg/kg; p.o.) abolishes MAP-KAPK-2 activity and HSP27 phosphorylation.
SB242235 inhibits expression of the pro-inflammatory cytokines interleukin (IL)-6 and KC (murine IL-8) and COX-2.
SB-242235 is demonstrated non-linear elimination kinetics that manifested as a decrease in clearance with increasing dose and apparent oral bioavailability > 100% at high oral doses in rat and monkey.

Animal Model:	Female SKH-1 hairless mice (4–6 weeks)
Dosage:	100 mg/kg
Administration:	Oral administered, 30 minutes prior to ultraviolet B (UVB) irradiation
Result:	Abolished MAP-KAPK-2 activity and heat shock protein 27 (HSP27) phosphorylation.

4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶上下游产品信息

上游原料

下游产品

4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶试剂级价格

更新日期：2024/11/08
产品编号：HY-18306
产品名称：4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶 SB 242235
CAS编号：193746-75-7
包装：5mg
价格：850元

更新日期：2024/11/08
产品编号：HY-18306
产品名称：4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶 SB 242235
CAS编号：193746-75-7
包装：10mM * 1mLin DMSO
价格：935元

4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶生产厂家

法国 1 美国 10 印度 1 英国 2 中国 55 全球 69 4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶国内生产厂家

公司名称：CHEMSWORTH
联系电话：--
电子邮件：info@chemsworth.com
国家：印度
产品数：6700
优势度：30

193746-75-7, 4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶相关搜索:

SB 743921; (R)-N-(3-AMINOPROPYL)-N-(1-(3-BENZYL-7-CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL)-4-METHYLBENZAMIDE HYDROCHLORIDE (2E)-3-[2-丁基-1-[2-(二乙基氨基)乙基]-1H-苯并咪唑-5-基]-N-羟基丙烯酰胺 SB225002 SB216763 3-苯基磺酰基-8-(哌嗪-1-基)喹啉 SB-3CT 6-氯-2,3-二氢-5-甲基-N-[6-[(2-甲基-3-吡啶基)氧]-3-吡啶基]-1H-吲哚-1-酰胺盐酸盐 3-[(3-氯-4-羟苯基)氨基]-4-(2-硝苯基)-1H-吡咯-2,5-二酮 4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑 SB-431542 5-[2-[4-[2-(二甲基氨基)乙氧基]苯基]-5-(4-吡啶基)-1H-咪唑-4-基]-2,3-二氢-1-茚酮肟 SB 269970盐酸盐 14-甲基-20-氧杂-5,7,14,27-四氮杂四环[19.3.1.1(2,6).1(8,12)]二十七碳-1(25),2,4,6(27),8,10,12(26),16,21,23-十烯 6-[2-(1,1-二甲基乙基)-5-(6-甲基-2-吡啶基)-1H-咪唑-4-基]喹喔啉 3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺 SB-705498 4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑 SB-505124

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