(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇

用途生物活性靶点体外研究体内研究 (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇试剂级价格

CAS号:158021-47-7
英文名:KRN7000
中文名:(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
CBNumber:CB0501572
分子式:C50H99NO9
分子量:858.32
MOL File:158021-47-7.mol

(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇化学性质

熔点 :125-130°C
沸点 :939.8±65.0 °C(Predicted)
密度 :1.04±0.1 g/cm3(Predicted)
储存条件 :-20°C Freezer
溶解度 :Pyridine (Slightly, Heated)
形态 :White solid.
酸度系数(pKa) :12.92±0.70(Predicted)
颜色 :White to Pale Beige
稳定性 :Hygroscopic
CAS 数据库 :158021-47-7

安全信息

WGK Germany :3
海关编码 :2940.00.6000

(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇性质、用途与生产工艺

用途 KRN7000主要用于实验室有机合成中和化工医药研发过程中，在小鼠的传染性和自身免疫性疾病中显示出免疫学作用。
生物活性 α-Galactosylceramide (α-GalCer) 是一种合成的糖脂，具有抗肿瘤和免疫刺激作用。α-Galactosylceramide 是一种非常有效的 NKT 细胞激动剂，可与 CD1d 有效结合。α-Galactosylceramide 与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。
靶点

NKT cell
体外研究

Culture supernatants of activated Vα24+NKT-cell cultures stimulated with α-Galactosylceramide pulsed monocyte-derived dendritic cells (Mo-DCs) exhibits antiproliferative activities against melanoma cells. This effect is predominantly due to release of IFN-γ, and to a lesser extent IL-12. Other cytokines, including IL-4 and IL-10, are released but these cytokines have less antiproliferative effects. Vα24+NKT-cells stimulated by α-Galactosylceramide-pulsed Mo-DCs have anti-tumour activities against human melanoma through antiproliferative effects exerted by soluble mediators.
体内研究

α-Galactosylceramide treatment can protect against spontaneous, carcinogen-, or oncogene-induced primary tumor formation in mice. Consistent with a prime role for IFN-γ in NKT cell-mediated tumor responses, a C-glycoside analog of α-Galactosylceramide that preferentially stimulated IFN-γ production is even more effective than α-Galactosylceramide at preventing metastases of the B16 melanoma.
Since α-Galactosylceramide shows a potent antitumor activity and stimulates the lymphocyte proliferation (LP) on allogeneic mixed lymphocyte reaction (MLR) in the mouse, α-Galactosylceramide is considered to be a nonspecific immunostimulating agent which is a biological response modifier.