ChemicalBook CAS数据库列表 巴佛洛霉素C 1
巴佛洛霉素C 1
- CAS号:88979-61-7
- 英文名:BAFILOMYCIN C1
- 中文名:巴佛洛霉素C 1
- CBNumber:CB0320023
- 分子式:C39H60O12
- 分子量:720.89
- MOL File:88979-61-7.mol
巴佛洛霉素C 1化学性质
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 5 mg/ml; Methanol: 5 mg/ml
- 形态 :White to light-brown solid.
- 颜色 :Yellow
巴佛洛霉素C 1性质、用途与生产工艺
- 生物活性 Bafilomycin C1 是从链霉菌中分离得到的大环内酯类抗生素 (antibiotic)。Bafilomycin C1 是一种有效的、特异性的、可逆的 vacuolar-type H+-ATPases 抑制剂。Bafilomycin C1 抑制革兰氏阳性菌 (bacteria) 和真菌 (fungi) 的生长。Bafilomycin C1 可诱导细胞凋亡 (apoptosis)，可用于肝细胞癌 (HCC) 的研究。
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体外研究
Bafilomycin C1 (0.33-10 μM; 6 days) inhibits the growth and proliferation of SMMC7721 and HepG2 cells in a timeand dose-dependent manner.Bafilomycin C1 (0.33-3.3 μM; 24 hours) decreases cyclin D3, cyclin E1, CDK2, CDK4, and CDK6 expression in both mRNA and protein expression in SMMC7721 cells.Bafilomycin C1 (3.3-10 μM; 24 hours) causes morphological alterations and increases the population of apoptotic cells by Hoechst 33258 (HY-15558) staining compared to vehicle.
Cell Viability Assay
Cell Line: SMMC7721 cell and HepG2 cell Concentration: 0.33 μM, 1.1 μM, and 3.3 μM for SMMC77211.1 μM, 3.3 μM, and 10.0 μM for HepG2 Incubation Time: 6 days Result: Retarded the cell growth. Western Blot Analysis
Cell Line: SMMC7721 cells Concentration: 3.3 μM Incubation Time: 24 hours Result: Decreaed cyclin D3/E1,CDK2/4/6 protein expression and increased p21. Apoptosis Analysis
Cell Line: SMMC7721 and HepG2 cells Concentration: 3.3 μM; 10 μM Incubation Time: 24 hours Result: Induced apoptosis in SMMC7721 and HepG2 cells. -
体内研究
Bafilomycin C1 (subcutaneous injection; 0.2 mg/kg; 20 days) retards the tumor growth without apparent adverse reactions or side effects in nude mice model.
Animal Model: BALB/c nude mice (weighing 18-20 g) subcutaneous injected by SMMC7721 cell suspension (5×10 6 cells/100 μL) Dosage: 0.2 mg/kg Administration: Subcutaneous injection; 20 days Result: Suppressed tumor growth of SMMC7721 tumor xenografts.
巴佛洛霉素C 1上下游产品信息
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下游产品
巴佛洛霉素C 1 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-130173
- 产品名称：巴佛洛霉素C 1 Bafilomycin C1
- CAS编号：88979-61-7
- 包装：1mg
- 价格：1980元
- 更新日期：2024/04/30
- 产品编号：HY-130173
- 产品名称：巴佛洛霉素C 1 Bafilomycin C1
- CAS编号：88979-61-7
- 包装：5 mg
- 价格：9800元
巴佛洛霉素C 1生产厂家
- 公司名称：CFMOT-PHYTO
- 联系电话：--
- 电子邮件：
- 国家：德国
- 产品数：1136
- 优势度：62
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