PIRONETIN
- CAS号:151519-02-7
- 英文名:PIRONETIN
- 中文名:PIRONETIN
- CBNumber:CB0303174
- 分子式:C19H32O4
- 分子量:324.45
- MOL File:151519-02-7.mol
- 熔点 :75-77 °C
- 沸点 :473.1±40.0 °C(Predicted)
- 密度 :0.993±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Dichloromethane: soluble; DMSO: soluble; Ethanol: soluble
- 形态 :A solid
- 酸度系数(pKa) :14.28±0.20(Predicted)
- 颜色 :Colorless to off-white
- 海关编码 :29419000
PIRONETIN性质、用途与生产工艺
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毒性
雄小鼠急性经口 LD500325mg/kg。Ames试验呈阴性。
- 生物活性 Pironetin 是从链霉菌属物种分离的 α/β 不饱和内酯。Pironetin 与 α-tubulin 结合，是微管聚合的有效抑制剂，具有细胞周期停滞和抗肿瘤活性。
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靶点
Microtubule
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体外研究
Pironetin (20-100 ng/mL; 24 hours; 3Y1 cells) treatment arrests the cell cycle progression at G2/M in 3Y1 cells.
Pironetin (1-10000 ng/mL; 3 days; HeLa, A2780 and K-NRK cells) treatment inhibits the cell proliferation. IC 50 values against these cell lines are almost 10 ng/mL.Cell Cycle Analysis
Cell Line: 3Y1 cells Concentration: 20 ng/mL, 50 ng/mL, 100 ng/mL Incubation Time: 24 hours Result: Arrested the cell cycle progression at G2/M in3Y1 cells. Cell Proliferation Assay
Cell Line: HeLa, A2780 and K-NRK cells Concentration: 1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL and 10000 ng/mL Incubation Time: 3 days Result: Inhibited the cell proliferation. -
体内研究
Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment shows a moderate antitumor effect, however, a severe weight loss is observed as a side effect.
Animal Model: Female CDF1-SLC mice (10 weeks) injected with P388 murine leukemia cells Dosage: 0.78 mg/kg, 1.56 mg/kg, 3.13 mg/kg, 6.25 mg/kg Administration: Intraperitoneal injection; daily; for 5 days Result: Showed a moderate antitumor effect. -
用途
水稻以100g/10公亩剂量处理水稻，对其地面部分抑制程度为18%～23%，以25g/10公亩剂量处理，则对地面部分几乎无抑制作用，在出穗前5～9d施用pironetin对产量无影响。小麦用125~1000mg/L的喷洒浓度处理旱田小麦，对株高呈现20%左右的生长抑制活性，但对小麦穗数并无影响。以2000mg/L处理对小麦有药害，平均每穗重及千粒重减少10%左右。
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用途
以5-甲基-2-庚烯为原料经以下步骤合成：
- 更新日期：2024/08/19
- 产品编号：HY-116446
- 产品名称：PIRONETIN Pironetin
- CAS编号：151519-02-7
- 包装：1mg
- 价格：8800元
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6315
- 优势度：74
