生物活性 靶点 体外研究 体内研究 旋覆花内酯 试剂级价格
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旋覆花内酯

旋覆花内酯,33627-41-7,结构式
旋覆花内酯
  • CAS号:33627-41-7
  • 英文名:inulicin
  • 中文名:旋覆花内酯
  • CBNumber:CB01361911
  • 分子式:C17H24O5
  • 分子量:308.37
  • MOL File:33627-41-7.mol
旋覆花内酯化学性质
  • 熔点 :124.0-126.1 °C
  • 沸点 :481.7±45.0 °C(Predicted)
  • 密度 :1.16
  • 储存条件 :4°C, protect from light
  • 溶解度 :DMSO: soluble
  • 形态 :A solid
  • 酸度系数(pKa) :13.71±0.60(Predicted)

旋覆花内酯性质、用途与生产工艺

  • 生物活性 Inulicin (1-O-Acetylbritannilactone) 是从 Inula Britannica L 分离的一种活性化合物。Inulicin (1-O-Acetylbritannilactone) 抑制 VEGF 介导的 Src 和 FAK 活化。Inulicin (1-O-Acetylbritannilactone) 还抑制 LPS 诱导的 PGE2 产生和 COX-2 表达,以及抑制 NF-κB 活化和易位。
  • 靶点

    NF-κB

    COX-2

  • 体外研究

    Inulicin (1-O-Acetylbritannilactone) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling. Inulicin dose-dependently inhibits vascular endothelial growth factor (VEGF)-induced proliferation, migration, and capillary structure formation of cultured human umbilical vascular endothelial cells (HUVECs). Treatment of A549 NSCLC cells with Inulicin results in cell growth inhibition and Src-FAK in-activation. The potential effect of Inulicin is tested ton Src and FAK phosphorylation in A549 lung cancer cells. Significant high levels of Src and FAK phosphorylations are noticed a in A549 cells, which are both inhibited by treatment of Inulicin (5 μM and 10 μM). Src and FAK are both important for cancer cell proliferation. Thus, A549 cell growth, tested by MTT assay and clonogenicity assay,is remarkably inhibited by corresponding Inulicin treatment. The anti-A549 cell growth activity of Inulicin is again dose-dependent. Inulicin (1-O-Acetylbritannilactone) isolated from Inula britannica-F. , inhibits inflammatory responses in vascular smooth muscle cells (VSMCs). Inulicin (5, 10, 20 μM) has several concentration dependent effects, including inhibition of lipopolysaccharide (LPS)-induced PGE 2 production and COX-2 expression, and blockade of NF-κB activation and translocation. In addition, Inulicin directly inhibits the binding of active NF-κB to specific DNA cis-element.

  • 体内研究

    Administration of a single dose of Inulicin (1-O-Acetylbritannilactone; 12 mg/kg/day) remarkably suppresses growth of A549 xenografts in nude mice. In vivo microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. To investigate the potential activity of Inulicin in vivo, a nude mice xenograft model is applied. A single dose of Inulicin (12 mg/kg/day, i.p.) dramatically inhibits the growth of A549 xenografts in nude mice. Further, the weights of Inulicin-treated tumors are remarkably lighter than that of vehicle-treated tumors. Notably, Inulicin administration does not affect mice body weights.

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旋覆花内酯 试剂级价格
  • 更新日期:2024/01/25
  • 产品编号:HY-N0896
  • 产品名称:旋覆花内酯 Inulicin
  • CAS编号:33627-41-7
  • 包装:1mg
  • 价格:650元
  • 更新日期:2024/01/25
  • 产品编号:HY-N0896
  • 产品名称:旋覆花内酯 Inulicin
  • CAS编号:33627-41-7
  • 包装:5mg
  • 价格:2000元
旋覆花内酯生产厂家
  • 公司名称:MedChemexpress LLC
  • 联系电话:021-58955995
  • 电子邮件:sales@medchemexpress.cn
  • 国家:美国
  • 产品数:4863
  • 优势度:58
  • 公司名称:TargetMol中国(陶术生物)
  • 联系电话:021-33632979 15002134094
  • 电子邮件:marketing@targetmol.com
  • 国家:中国
  • 产品数:7934
  • 优势度:58
  • 公司名称:雷丁试剂
  • 联系电话:0510-85629785 18013409632
  • 电子邮件:sales@reading-chemicals.com
  • 国家:中国
  • 产品数:15185
  • 优势度:58
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