基本信息 物理化学性质 常见问题列表 供应商 相关产品
网站主页Cas数据库列表99107-52-5

99107-52-5

中文名称 布那司特
英文名称 1-Acetoxy-2-butyl-4-methoxynaphtalene
CAS 99107-52-5
分子式 C17H20O3
分子量 272.34
MOL 文件 99107-52-5.mol
结构式 99107-52-5 结构式

基本信息

中文别名 布那司特
英文别名 U-66858
Bunaprolast
1-Acetoxy-2-butyl-4-methoxynaphtalene
1-Acetoxy-2-butyl-4-methoxynaphthalene
1-acetoxy-2-n-butyl-4-methoxynaphthalene
1-Naphthalenol, 2-butyl-4-methoxy-, 1-acetate

物理化学性质

储存条件 -20°C储存
溶解度 溶于二甲基亚砜

常见问题列表

生物活性
Bunaprolast (U66858) 是白三烯 B4 (LTB4) 的有效抑制剂。Bunaprolast (U66858) 也抑制脂氧合酶 (lipoxygenase),以及 TXB2 释放。
靶点

LTB 4

TXB 2

5-LO

体外研究

Bunaprolast (U-66,858) undergoes deacetylation to an initial metabolite with similar pharmacological potency. The inhibitory effects of the semi-quinone Bunaprolast and its metabolite U-68,244 on the ionophore-induced formation of leukotriene B4 (LTB4) are examined in human whole blood (WB). Preincubation of Bunaprolast and U-68,244 for 1 min prior to challenge of blood with calcium ionophore A23187 results in IC 50 s of 1080±644 and 820±442 nM, respectively. After 60 min preincubation, IC 50 s are 250±85 and 270±79 nM. The activity of the lipoxygenase inhibitor AA-861 in this system is similar to that of Bunaprolast, while vitamin K and the sulphate conjugate of Bunaprolast show significant inhibition of LTB4 release only at micromolar concentrations. Bunaprolast exhibits significant inhibition of thromboxane A2 release (p<0.02) in a comparative study with the known cyclooxygenase (CO) inhibitor Flurbiprofen.

体内研究

The IgE-mediated hypersensitivity to Ascaris antigen in reactor rhesus primates is used to assess the pharmacologic profile of Bunaprolast (U-66,858). When Bunaprolast is given by the oral route, it shows dose-related inhibition of resistance (RL) and compliance (Cdyn) changes. When Bunaprolast is given by the aerosol route, it shows dose independent inhibition. In 15 animals, aerosols (52±32 to 53±10% for RL, p=0.05 and 45±19 to 28±19% Cdyn inhibitions, p=0.05) for 5.0-0.1% aerosol. By the oral route, inhibition is seen at 1-4 h following administration. In 5 animals, oral doses of 10 and 5 mg/kg inhibit (RL by 98±2 to 78±1.5%, p=0.01 and Cdyn by 75±17 to 60.9±9.1%, p=0.05) by 10 and 5 mg/kg Bunaprolast, respectively.

供应商信息 更多

成都超九八生物科技有限公司
联系电话: 13348960310 13348960310
产品介绍:
中文名称:布那司特
英文名称:Bunaprolast
CAS:99107-52-5
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg
天津普西唐生物医药科技有限公司
联系电话: 010-60605840 15801484223
产品介绍:
英文名称:Bunaprolast
CAS:99107-52-5
包装信息:100mg
备注: 试剂级
常州博嘉生物医药科技有限公司
联系电话: 2122619822
产品介绍:
英文名称:99107-52-5
CAS:99107-52-5
纯度:99% HPLC
包装信息:1G;5G;10G;100G;1KG;
备注:医药级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:布那司特
英文名称:Bunaprolast
CAS:99107-52-5
纯度:99.9%
包装信息:5mg/RMB 12600;1mg/RMB 4900
上海一研生物科技有限公司
联系电话: 021-69985186 13611928337
产品介绍:
英文名称:Bunaprolast (U66858)
CAS:99107-52-5
备注:1盒

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