95853-92-2
基本信息
化合物CGS 15435
1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-
物理化学性质
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P305+P351+P338 |
常见问题列表
|
TXA 2 1 nM (IC 50 ) |
CGS 15435 is a highly specific Tx synthetase inhibitor. CGS 15435 is only weakly effective as an inhibitor of PGE 2 (Cyclooxygenase, IC 50 =1200 μM), prostacyclin (PGI 2 synthetase, IC 50 =90 μM) or 5-Lipoxygenase (IC 50 =60 μM) product formation.
CGS 15435 has a long duration of action, since the increases in the plasma levels of TxB 2 are prevented even at 24 h after CGS 15435 administration. CGS 15435 significantly inhibits TxB 2 formation 4, 6, 12 and 24 h after dosing. Administration of CGS 15435 0.25 or 24 h prior to Arachidonic acid (AA) produced no increase in TxB 2 in the surviving animals (4/4 and 5/6, respectively). The final TxB 2 levels in the CGS15435A (0.25 and 24 h pretreatment) groups are significantly lower (P<0.05) than those seen in the AA or the Dazoxiben (2 h pretreatment) groups.