931417-26-4
物理化学性质
| 沸点 | 443.0±45.0 °C(Predicted) |
| 密度 | 1.398±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | DMSO: 20.83 mg/mL (79.17 mM) |
| 酸度系数(pKa) | 15.79±0.50(Predicted) |
| 形态 | Solid |
| 颜色 | Light yellow to yellow |
| InChI | 1S/C13H8Cl2N2/c14-12-4-3-9(7-13(12)15)10(8-16)6-11-2-1-5-17-11/h1-7,17H/b10-6+ |
| InChIKey | IJJHHDLGGYDXGD-UXBLZVDNSA-N |
| SMILES | ClC1=CC(/C(C#N)=C/C2=CC=CN2)=CC=C1Cl |
安全数据
| WGK Germany | WGK 3 |
| 存储类别 | 11 - Combustible Solids |
化合物 T10325价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/06/05 | HY-117102 | 化合物 T10325 ANI-7 | 931417-26-4 | 5mg | 400元 |
| 2026/06/05 | HY-117102 | 化合物 T10325 ANI-7 | 931417-26-4 | 10mM * 1mLin DMSO | 440元 |
| 2026/06/05 | HY-117102 | 化合物 T10325 ANI-7 | 931417-26-4 | 10mg | 666元 |
常见问题列表
|
Aryl Hydrocarbon Receptor
|
Chk2
|
ANI-7 (2.5 μM; 24 hours; MCF10A and MDA-MB-468 cells) treatment induces significant S-phase and G2 + M-phase cell cycle arrest within 24 hours of treatment in MDA-MB-468 cells, and negligible effect in normal breast MCF10A cells.
ANI-7 (2 μM; 12-24 hours; MDA-MB-468 cells) treatment results in a significant increase in the content and phosphorylation of CHK2, and induces a significant increase in H2AXɣ in MDA-MB-468 cells, indicative of DNA double-strand damage.
Inhibition of the AhR pathway ameliorates the effects of ANI-7. ANI-7 activates XRE activity and expression of the AhR and CYP1 members.
Comparisons of the GI
50
values show that ANI-7 produces a GI
50
value of 0.38 μM in MCF-7 cells, whereas values of 3.0-42 μM are observed in cell lines from lung, colon, ovary, neuronal, glial, prostate, and pancreas. The only other tumor type that shows appreciable growth inhibition by ANI-7 is the A431 vulva cell line (GI
50
of 0.51μM).
ANI-7 potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells (GI
50
range of 0.16-0.38 μM), moderately inhibits the growth of BT20 and BT474 cells (GI50 range of 1-2 μM), and essentially fails to inhibit the growth of MDA-MB-231 and MCF10A cells (GI
50
range of 17-26 μM). Moreover, ANI-7 maintained its ability to inhibit the growth of drug-resistant cells (MCF-7/VP16: GI
50
of 0.21 μM).
Cell Cycle Analysis
| Cell Line: | MCF10A and MDA-MB-468 cells |
| Concentration: | 2.5 μM |
| Incubation Time: | 24 hours |
| Result: | Induced significant S-phase and G2 + M-phase cell cycle arrest in MDA-MB-468 cells, and negligible effect in normal breast MCF10A cells. |
Western Blot Analysis
| Cell Line: | MDA-MB-468 cells |
| Concentration: | 2 μM |
| Incubation Time: | 12 hours, 24 hours |
| Result: | Resulted in a significant increase in the content and phosphorylation of CHK2 (25-fold increase),and induced a significant increase in H2AXɣ (3.5-fold increase). |