877950-01-1
基本信息
化合物LTAS-IN-1
(5-phenyl-1,3,4-oxadiazol-2-yl)carbamoyl]methyl 2-{naphtho[2,1-b]furan-1-yl}acetate
2-oxo-2-((5-phenyl-1,3,4-oxadiazole-2-yl)amino-)ethyl 2-(naphtho[2,1-b]furo-1-yl)acetate
Naphtho[2,1-b]furan-1-acetic acid, 2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl ester
Bacterial,MDR,E. faecium,LtaSIN1,multidrug-resistant,inhibit,LtaS IN 1,anti-bacterial,Inhibitor
物理化学性质
| 密度 | 1.400±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.67±0.70(Predicted) |
| 形态 | Solid |
| 颜色 | Light yellow to yellow |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H335-H319-H315-H302 |
| 防范说明 | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
LtaS-IN-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-135813 | LtaS-IN-1 | 877950-01-1 | 1 mg | 681元 |
| 2025/02/08 | HY-135813 | LtaS-IN-1 LtaS-IN-1 | 877950-01-1 | 5mg | 1500元 |
| 2025/02/08 | HY-135813 | LtaS-IN-1 LtaS-IN-1 | 877950-01-1 | 10mM * 1mLin DMSO | 1650元 |
常见问题列表
MIC: 0.5 μg/mL (strain E1630); 0.5 μg/mL (strain E1590)
LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with the MIC values of 0.5μg/mL. LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively.