853136-76-2
中文名称
化合物 T27187
英文名称
4-Oxazolecarboxamide, 2-[[[3,4,5,6,7,8-hexahydro-4-oxo-3-(phenylmethyl)[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]methyl]-N-[2-(1-pyrrolidinyl)ethyl]-
CAS
853136-76-2
分子式
C28H31N5O3S2
分子量
549.71
MOL 文件
853136-76-2.mol
结构式
基本信息
中文别名
化合物 T27187
英文别名
DK149
DK-1-49
DK 1 49
4-Oxazolecarboxamide, 2-[[[3,4,5,6,7,8-hexahydro-4-oxo-3-(phenylmethyl)[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]methyl]-N-[2-(1-pyrrolidinyl)ethyl]-
DK-1-49
DK 1 49
4-Oxazolecarboxamide, 2-[[[3,4,5,6,7,8-hexahydro-4-oxo-3-(phenylmethyl)[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]methyl]-N-[2-(1-pyrrolidinyl)ethyl]-
物理化学性质
| 密度 | 1.45±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 13.44±0.46(Predicted) |
应用领域
用途一
DK-1-49 is an autophagonizer. DK-1-49 causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles. Furthermore, cell viability is inhibited by autophagic cell death in not only human cancer cells but also Bax/Bak double-knockout cells.