847612-12-8
中文名称
化合物 T26681
英文名称
ATL-802
CAS
847612-12-8
分子式
C24H22F3N7O3
分子量
513.47
MOL 文件
847612-12-8.mol
结构式
物理化学性质
| 沸点 | 738.0±70.0 °C(Predicted) |
| 密度 | 1.481±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 10.62±0.20(Predicted) |
应用领域
用途一
ATL802 is an adenosine A2B Receptor antagonist. After IR, ATL802 treatment significantly improved lung function (increased pulmonary compliance and reduced airway resistance and pulmonary artery pressure) and significantly attenuated proinflammatory cytokine production, neutrophil infiltration, vascular permeability, and edema. ATL802 also significantly improved the function of DCD lungs after EVLP (increased compliance and reduced pulmonary artery pressure). After HR, A549 cells exhibited robust production of interleukin (IL)-8, a potent neutrophil chemokine, which was significantly attenuated by ATL802.
常见问题列表
概述
ATL-802 是一种强效的腺苷 A2B receptor 拮抗剂。ATL-802 有望用于糖尿病的研究。