82989-25-1
基本信息
他扎司特
化合物 T17001
丁基-3'-(1H-四唑-5-基)苯酰羧酸
TO-188
Tazanol
Tazalest
TAZANOLAST
Tazanolast(Tazalest,TO 188,WP 833)
Butyl 3'-(1H-tetrazol-5-y1)oxanilate
butyl 2-oxo-2-[3-(2H-tetrazol-5-yl)anilino]acetate
N-[3-(1H-Tetrazol-5-yl)phenyl]oxamidic acid butyl ester
Butyl 2-((3-(1H-tetrazol-5-yl)phenyl)aMino)-2-oxoacetate
物理化学性质
| 外观性状 | 白色或带黄白色结晶或结晶性粉末，略臭，味苦。易溶于丙酮，较易溶于甲醇、乙醇或乙腈，难溶于乙醚，几不溶于水。急性毒性LD50雄、雌小鼠，雄、雌大鼠(mg/kg)：＞4000，＞4000，＞4000，＞4000口服；＞4000，＞4000，＞4000，＞4000皮下注射；1145，1191，1423，1528腹腔注射；1126，1121，1119，1277静脉注射。 |
| 密度 | 1.343 |
| 储存条件 | 2-8°C |
| 溶解度 | Soluble in DMSO |
| 酸度系数(pKa) | 4.06±0.10(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
应用领域
制备方法
上下游产品信息
他扎司特价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-101810 | 他扎司特 Tazanolast | 82989-25-1 | 1mg | 3831元 |
| 2025/02/08 | HY-101810 | 他扎司特 Tazanolast | 82989-25-1 | 10 mM * 1 mLin DMSO | 12191元 |
常见问题列表
Tazanolast, an orally active mast-cell-stabilizing drug, which has been shown to suppress passive cutaneous anaphylaxis, Schultz-Dale reaction in isolated tracheal muscle, and experimental asthma without antagonistic actions upon histamine- and leukotriene-D4-induced contraction, IgE-mediated or compound 48/80-induced histamine release from mast cells and lung fragments, compound 48/80-induced Ca 2+ uptake into mast cells from extracellular medium, compound 48/80-induced translocation of protein kinase C from the cytosol to the membrane fraction of mast cells, and inositol trisphosphate production without directly inhibiting phospholipase C in mast cells.
Tazanolast administered before ozone exposure at doses of 30, 100, or 300 mg/kg inhibits ozone-induced airway hyperresponsiveness in a dose-dependent manner. Tazanolast administered after ozone exposure does not inhibit the airway hyperresponsiveness. Tazanolast does not significantly change the cell distribution of bronchoalveolar lavage (BAL) cells at 2 h after the exposure. Tazanolast significantly inhibits ozone-induced airway hyperresponsiveness in guinea pigs.