78299-79-3
中文名称
2,3-dihydro-7-methyl-9-phenyl-1H-pyrazolo(1,2-a)indazolium
英文名称
2,3-dihydro-7-methyl-9-phenyl-1H-pyrazolo(1,2-a)indazolium
CAS
78299-79-3
MOL 文件
78299-79-3.mol
结构式
物理化学性质
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
安全数据
| 毒性 | LD50 oral in rat: 1380mg/kg |
常见问题列表
生物活性
FKK 是一种吲唑衍生物，也是一种新型支气管扩张剂。
体内研究
FKK is an indazole derivative and also a novel bronchodilator. FKK (0.1 to 3.0 mg/kg, i.v.) slightly increases respiratory frequency, left ventricular (LV) dp/dt max and myocardial contractile force. A slight increase followed by a decrease is observed in systemic blood pressure and LV systolic pressure. FKK causes direct vasodilation in the coronary, mesenteric and femoral vasculatures, but has no effect on the renal vasculature. It is particularly pertinent that FKK (30 mg/kg, i.d., enough to cause marked bronchodilation), unlike aminophylline (30 mg/kg, i.d.), does not significantly influence the cardiovascular system.