78090-11-6
基本信息
Picoprazole
5-methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-Benzimidazole-6-carboxylic acid Methyl ester
6-Methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-5-carboxylic acid methyl ester
1H-Benzimidazole-6-carboxylic acid, 5-methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-, methyl ester
物理化学性质
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P305+P351+P338 |
常见问题列表
IC50: 3.1±0.4 μM (H + /K + -ATPase)
Picoprazole inhibits the H + /K + -ATPase activity in a concentration-dependent manner. The IC 50 value is 3.1±0.4 μM. Picoprazole is a specific inhibitor of H + /K + -ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl - conductance by Cu 2+ -o-phenanthroline, indicating that the Cl - conductance is part of the function of the H + /K + -ATPase. The inhibitory effect of the three benzimidazole derivatives Timoprazole, Picoprazole, and Omeprazole on histamine and dbcAMP stimulated 14 C-aminopyrine accumulation (H + secretion) has been studied in isolated and enriched guinea-pig parietal cells. All compounds tested inhibit H + secretion in a concentration dependent manner with IC 50 values of 8.5±1.9 μM for Timoprazole, 3.9±0.7 μM for Picoprazole, and 0.13±0.03 μM for Omeprazole.