63676-25-5
中文名称
N/A
英文名称
Phenethipylone
CAS
63676-25-5
分子式
C27H25NO4S
分子量
459.56
MOL 文件
63676-25-5.mol
结构式
基本信息
中文别名
化合物 T15800
英文别名
LY 117018
Ly 139478
Lilly 117018
Phenethipylone
6-Hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl 4-(2-(1-pyrrolidinyl)ethoxy) phenyl ketone
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone
Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-
[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone
Ly 139478
Lilly 117018
Phenethipylone
6-Hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl 4-(2-(1-pyrrolidinyl)ethoxy) phenyl ketone
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone
Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-
[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone
物理化学性质
| 形态 | Solid |
| 颜色 | Light yellow to yellow |
常见问题列表
生物活性
LY117018，Raloxifene 类似物，是一种选择性雌激素受体 (estrogen receptor) 调节剂。LY117018 对乳腺癌细胞具有抗增殖作用。
靶点
|
Estrogen receptor
|
体外研究
LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation.
LY117018 (1 μM; 96 hours) inhibits MCF-7 cells proliferation with an IC
50
of 1 μM.
LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.
Cell Proliferation Assay
| Cell Line: | MCF-7 cells |
| Concentration: | 1 μM |
| Incubation Time: | 96 hours |
| Result: | Inhibited MCF-7 cells proliferation with an IC 50 of 1 μM. |
供应商信息 更多
四川省维克奇生物科技有限公司
联系电话：
028-81700200 18116577057
产品介绍：
中文名称：暂无
英文名称：LY117018
CAS：63676-25-5
纯度：98%
包装信息：5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
上海修时生物医药有限公司
联系电话：
15021598081,571034478; 15021598081
产品介绍：
英文名称：Phenethipylone
CAS：63676-25-5
纯度：95%H NMR
包装信息：5KG;1KG;100g;25g;10g;5g;1g
天津普西唐生物医药科技有限公司
联系电话：
010-60605840 15801484223
产品介绍：
英文名称：LY117018
CAS：63676-25-5
包装信息：5mg
备注： 试剂级
TargetMol中国（陶术生物）
联系电话：
4008200310
产品介绍：
中文名称：化合物 LY117018
英文名称：LY117018
CAS：63676-25-5
包装信息：100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600