56563-17-8
中文名称
PLURISIN #2
英文名称
1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl-
CAS
56563-17-8
分子式
C11H8FN3O3
分子量
249.2
MOL 文件
56563-17-8.mol
更新日期
2023/03/20 15:41:25
结构式
物理化学性质
| 熔点 | 223 °C |
| 密度 | 1.51±0.1 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| 溶解度 | DMSO: 5 mg/mL (20.06 mM) |
| 酸度系数(pKa) | 6.88±0.10(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
常见问题列表
生物活性
PluriSIn #2 是一种拓扑异构酶 II α (TOP2A) 的选择性转录抑制剂。PluriSIn #2 是一种选择性消除未分化的人类多能干细胞 (hPSC) 的化合物。
靶点
|
topoisomerase II alpha
|
体外研究
PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level.
A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them.
Western Blot Analysis
| Cell Line: | B153 and HUES9 human pluripotent stem cells (hPSCs) |
| Concentration: | 20 µM |
| Incubation Time: | 12 hours |
| Result: | Reduced TOP2A expression at the protein level. |