501010-05-5
中文名称
GGTI-2417
英文名称
GGTI-2417
CAS
501010-05-5
分子式
C24H33N5O4
分子量
455.55
MOL 文件
501010-05-5.mol
结构式
基本信息
中文别名
化合物 T27412
英文别名
GGTI-2417
Reaxys ID: 11071519
GGTI 2417 (GGTI2417)
DWKYALWDWAYMTB-FPOVZHCZSA-N
L-Leucine, N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-, methyl ester
Reaxys ID: 11071519
GGTI 2417 (GGTI2417)
DWKYALWDWAYMTB-FPOVZHCZSA-N
L-Leucine, N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-, methyl ester
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H335-H319-H315 |
| 防范说明 | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 |
应用领域
用途一
GGTI2417 is a potent and selective Geranylgeranyltransferase I inhibitor that targets RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. By expressing farnesylated, GGTI-resistant RalA and RalB in Cos7 cells and human pancreatic MiaPaCa2 cancer cells followed by GGTI-2417 treatment, it was demonstrated that farnesylated RalB, but not RalA, confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of GGTI-2417.