376640-41-4
基本信息
3-氯-2-甲基-N-(4-(2-(4-甲基哌嗪-1-基)-2-氧代乙基)噻唑-2-基)苯磺酰胺
BVT 2733(BVT.2733)
BVT.2733 >=98% (HPLC)
3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide
BENZENESULFONAMIDE, 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL]-2-THIAZOLYL]-
3-CHLORO-2-METHYL-N-[4-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHYL]-1,3-THIAZOL-2-YL]BENZENESULFONAMIDE
物理化学性质
| 沸点 | 636.9±65.0 °C(Predicted) |
| 密度 | 1.427±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | ≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| 酸度系数(pKa) | 6.36±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | Off-white to pink |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302 |
| 防范说明 | P301+P312+P330 |
| 海关编码 | 2935909099 |
BVT 2733价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | S0209 | BVT 2733 BVT 2733 | 376640-41-4 | 5mg | 657.46元 |
| 2024/08/19 | S0209 | BVT 2733 BVT 2733 | 376640-41-4 | 25mg | 2383.47元 |
常见问题列表
| Target | Value |
|
11β-HSD1
() |
BVT 2733 (100 μM; 24 hours) co-treatment with PA (100 µM) reduces MCP-1 expression in fully differentiation adipocytes.BVT 2733 (50-100 μM; 24 hours) reduces the inflammation protein levels (MCP-1, IL-6) in medium in J774.1 macrophages by Elisa.
RT-PCR
| Cell Line: | Differentiation adipocytes |
| Concentration: | 100 μM |
| Incubation Time: | 24 hours |
| Result: | Down-regulated MCP-1 mRNA level. |
BVT-2733 (oral administration; 100 mg/kg; twice daily; 2 weeks) attenuates the arthritis severity and anti-CII level and decreases the levels of serum TNF-α, IL-1β, IL-6 and IL-17 in CIA mice.BVT 2733 (oral administration; 100 mg/kg; dosed (09.00 and 17.00 h); last 4 weeks) exhibits decreased body weight and enhanced glucose tolerance and insulin sensitivity when it compares to control mice. It also down-regulated the expression of inflammation-related genes including monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α) and the number of infiltrated macrophages within the adipose tissue in vivo.
| Animal Model: | Collagen-induced arthritis (CIA) mice |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration; twice daily; 2 weeks |
| Result: | Reduced synovial inflammation and joint destruction. |
| Animal Model: | C57BL/6J mice |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration; dosed (09.00 and 17.00 h); last 4 weeks |
| Result: | Improved metabolic homeostasis and suppressed the inflammation of adipose tissue in diet-induced obese mice. |