335276-86-3
中文名称
化合物 T6702L
英文名称
Propanoic acid, 2-hydroxy-, compd. with N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine (1:1)
CAS
335276-86-3
分子式
C24H31NO3
分子量
381.52
MOL 文件
335276-86-3.mol
结构式
基本信息
中文别名
化合物 T6702L
英文别名
DRG-0286
Lamisil Krem
Terbinafine lactate
SF 86-327 hydrochloride
Propanoic acid, 2-hydroxy-, compd. with N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine (1:1)
Lamisil Krem
Terbinafine lactate
SF 86-327 hydrochloride
Propanoic acid, 2-hydroxy-, compd. with N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine (1:1)
应用领域
用途一
Terbinafine is a synthetic allylamine antifungal, is used topically for skin infections. Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and dichloromethane, soluble in ethanol, and slightly soluble in water. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis. (last updated: 8/11/2016).