298708-81-3
基本信息
Bayer 41-4109
BAY41-4109
BAY-41-4109
BAYER 41-4109
methyl (R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4R)-
物理化学性质
| 沸点 | 475.3±45.0 °C(Predicted) |
| 密度 | 1.46±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | DMSO : 100 mg/mL (252.68 mM);Water : < 0.1 mg/mL (insoluble) |
| 酸度系数(pKa) | 5.43±0.60(Predicted) |
| 形态 | Solid |
| 颜色 | Light yellow to yellow |
298708-81-3价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-100029 | 298708-81-3 Bay 41-4109 | 298708-81-3 | 5mg | 1300元 |
| 2024/11/08 | HY-100029 | 298708-81-3 Bay 41-4109 | 298708-81-3 | 10mg | 2200元 |
| 2024/08/19 | HY-100029 | 298708-81-3 Bay 41-4109 | 298708-81-3 | 50mg | 7800元 |
常见问题列表
IC50&Target: 53 nM (HBV)
BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro . Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC 50 s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.
BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.