288847-34-7
中文名称
CA1P
英文名称
CA1P
CAS
288847-34-7
分子式
C18H23NaO12P2
分子量
516.31
MOL 文件
288847-34-7.mol
结构式
基本信息
中文别名
康普立停 A1 二磷酸酯四钠盐
英文别名
CA1P
OXi-4503 sodium
Tetrasodium A1 Diphosphate
COMBRETASTATIN A-1 PHOSPHATE
TetrasodiuM coMbretastatin A1 diphosphate
Oxi 4503 Combretastatin A-1 phosphate , CA1P
CoMbretastatin A1 diphosphate tetrasodiuM salt
tetrasodium,[3-methoxy-2-phosphonooxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate
3-Methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]-1,2-benzenediol bis(dihydrogen phosphate) tetrasodium salt
OXi-4503 sodium
Tetrasodium A1 Diphosphate
COMBRETASTATIN A-1 PHOSPHATE
TetrasodiuM coMbretastatin A1 diphosphate
Oxi 4503 Combretastatin A-1 phosphate , CA1P
CoMbretastatin A1 diphosphate tetrasodiuM salt
tetrasodium,[3-methoxy-2-phosphonooxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate
3-Methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]-1,2-benzenediol bis(dihydrogen phosphate) tetrasodium salt
所属类别
有机原料：芳香烃
应用领域
用途一
OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue.