27060-70-4
中文名称
Pentagamavunon-1
英文名称
Pentagamavunon-1
CAS
27060-70-4
分子式
C23H24O3
分子量
348.43
MOL 文件
27060-70-4.mol
更新日期
2023/03/20 15:41:23
结构式
![27060-70-4 结构式](https://www.chemicalbook.com/CAS/20210111/GIF/27060-70-4.gif)
物理化学性质
沸点 | 562.1±50.0 °C(Predicted) |
密度 | 1.232±0.06 g/cm3(Predicted) |
储存条件 | -20°C储存 |
溶解度 | DMSO: 50 mg/mL (143.50 mM) |
酸度系数(pKa) | 10.12±0.40(Predicted) |
形态 | Solid |
颜色 | Light yellow to yellow |
常见问题列表
生物活性
Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物,具有口服活性,通过多个机制诱导凋亡信号,如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。
体外研究
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20 µM) enhances cytotoxic effect of 5-FU on WiDr cells.
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, and 10 µM) shows different effects on cell cycle progression and induces G2/M arrest.
Cell Viability Assay.
Cell Line: | Human colon carcinoma WiDr. |
Concentration: | 1, 2.5, 5, 7.5, 10, 15, and 20 µM. |
Incubation Time: | 6, 12, 24, and 48 hours. |
Result: | Significantly enhanced the cytotoxicity of 5-FU on WiDr cells at various concentrations during 6, 12, 24, and 48 h incubation. |
Cell Cycle Analysis.
Cell Line: | WiDr cells. |
Concentration: | 1, 2.5, 5, and 10 µM. |
Incubation Time: | 24 h. |
Result: | The non-treated WiDr cells showed cell accumulation in G1, S, and G2/M phase about 50.85%, 36.11% and 13.04%, respectively. |
体内研究
Pentagamavunon-1 (PGV-1, po, 20 mg/kg) exhibits significant anti-tumor activity in PDX model, without obvious toxicity.
Animal Model: | Human cancer cells in a xenograf mouse model. |
Dosage: | 20mg/kg. |
Administration: | P.O. every 2 days for 20 days. |
Result: | Exhibited little decrease in body weight, nor a decrease in white and red blood cell counts in peripheral blood, nor any other efects in behavior and macroscopic appearance. Thus, PGV-1 was sufciently potent to suppress tumor formation in vivo, but exhibited little or no obvious adverse effects on the normal lineage of cells. |
供应商信息 更多
北京普西唐生物科技有限公司
联系电话:
010-60605840 18892239720
产品介绍:
英文名称:Pentagamavunon-1
CAS:27060-70-4
纯度:98%
包装信息:5mg
上海林栎医药科技有限公司
联系电话:
13761635123
产品介绍:
英文名称:Pentagamavunon-1
CAS:27060-70-4
纯度:>95%
包装信息:1G,5G
备注:现货
ChemeGen 中国
联系电话:
18818260767
产品介绍:
英文名称:Pentagamavunon-1
CAS:27060-70-4
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
TargetMol中国(陶术生物)
联系电话:
4008200310
产品介绍:
中文名称:化合物 Pentagamavunon-1
英文名称:Pentagamavunon-1
CAS:27060-70-4
纯度:98%
包装信息:500 mg
上海陌孚医药科技有限公司
联系电话:
021-59167510 18117107507
产品介绍:
英文名称:Pentagamavunon-1
CAS:27060-70-4
纯度:>=99%
包装信息:50mg;10mM*1mLinDMSO;200mg;10mg;100mg;500mg
銳迪國際科技有限公司
联系电话:
18024082417
产品介绍:
英文名称:Pentagamavunon-1
CAS:27060-70-4
纯度:5mg;10mg;50mg;100mg;250mg;500mg;1g
包装信息:5mg;10mg;50mg;100mg;250mg;500mg;1g