2553217-91-5
物理化学性质
| 沸点 | 523.9±30.0 °C(Predicted) |
| 密度 | 1.097±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | DMSO: 10 mM |
| 酸度系数(pKa) | 14.79±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | White to yellow |
常见问题列表
BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative ( B. theta VPI-5482, Bacteroides fragilis ATCC 25285, and Bacteroides vulgatus ATCC 8482) and Gram-positive ( Lactobacillus plantarum WCFS1, C. perfringens ATCC 13124, and Bifidobacterium adolescentis L2-32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC 50 s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively.
BSH-IN-1 (Compound 7; 10 mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted.
| Animal Model: | C57BL/6 mice |
| Dosage: | 10 mg/kg |
| Administration: | Single gavage |
| Result: | Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community. |