24345-16-2
基本信息
蜂针液明肽
APAMIN毒素肽
毒素多肽APAMIN
蜂毒明肽 (蜂针液明肽)
蜂毒明肽, ≥97% (HPLC)
APAMIN
apamine
APAMIN, BEE VENOM
Apamin, ≥97% (HPLC)
APAMIN FROM BEE VENOM
CNCKAPETALCARRCQQH-NH2
APAMIN FROM HONEY BEE VENOM
Apamin (trifluoroacetate salt)
M.W. 2027.34 C79H131N31O24S4
APAMIN (HONEYBEE, APIS MELLIFERA)
物理化学性质
| 沸点 | 847.17°C (rough estimate) |
| 密度 | 1.63 |
| 折射率 | 1.5530 (estimate) |
| 储存条件 | -20°C |
| 溶解度 | 0.05 M acetic acid: 5 mg/mL, clear, colorless to faintly yellow |
| 溶解度 | 0.05 M 乙酸：5 mg/mL，澄清，无色至淡黄色 |
| 形态 | White solid with dark tan cast |
| 颜色 | White to off-white |
| 水溶解性 | Soluble to 1 mg/ml in water |
| Merck | 13,732 |
安全数据
| 危险性符号(GHS) |  GHS08 |
| 警示词 | 危险 |
| 危险性描述 | H334 |
| 防范说明 | P261-P342+P311 |
| 安全说明 | 22-24/25 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| WGK Germany | 3 |
| RTECS号 | CD6899900 |
| F | 3-10 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 毒性 | LD50 i.v. in mice: 4 mg/kg (Habermann, Reiz); LD50 intracerebroventricularly in mice: 12 ng/animal (Labbé-Jullié) |
常见问题列表
蜂毒明肽是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素，是一种 Ca2+ 激活的 K+ (SK) 通道的特异性和选择性的阻断剂，具有抗炎和抗纤维化的作用。
(1)对神经系统作用：能阻断支配胃肠道平滑肌神经的抑制性冲动的传导，使胃肠平滑肌兴奋性增强，而呈收缩状态；可作用于脊髓的中间 神经元、下行的网状脊髓束和前庭脊髓束，或大脑导水管周围的中央灰 质，影响动作的有机协同。 (2) 强心、抗心律失常作用：具有很强的p-肾上腺素样作用，扩冠， 增加心肌供血，使心肌收缩力明显增强，心率加快，心脏泵血功能增强， 可用于治疗心衰；具有异丙肾上腺素样作用，且比异丙肾上腺素维持时间 长（约10倍），抗心律失常。(3) 增加毛细血管的通透性，改善微循环。 (4) 抗炎、调整免疫：直接升高血浆皮质醇或刺激垂体-肾上腺系统 促进皮质激素的分泌；抑制5-羟色胺活性。(5) 营养修复肌营养不良细胞：强直肌肉中有蜂毒明肽受体，蜂毒明肽通过与其受体结合而发挥营养肌细胞达到治疗的作用。可用于治疗强直性脊柱炎、多发性硬化症。
K + channel
Apamin (0.5-2 µg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1.
Western Blot Analysis
| Cell Line: | HSC-T6 cells |
| Concentration: | 0.5 µg/mL, 1 µg/mL and 2 µg/mL |
| Incubation Time: | 24 hours |
| Result: | Markedly reduced the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Abrogated the activation of p-Smad2/3 and Smad4 induced by TGF-β1. |
Apamin (0.1 mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice.
| Animal Model: | 8-week-old C57BL/6 male mice (20-25 g) with DDC feeding |
| Dosage: | 0.1 mg/kg |
| Administration: | Intraperitoneal injection; twice a week; for 4 weeks |
| Result: | Resulted in decreased liver injury and proinflammatory cytokine levels. Suppressed the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the DDC-fed mice. |
蜂毒明肽价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/11 | XW2434516201 | 蜂毒明肽 | 24345-16-2 | 1MG | 1455元 |
| 2024/11/08 | HY-P0256 | 蜂毒明肽 Apamin | 24345-16-2 | 500μg | 1500元 |
| 2024/11/08 | HY-P0256 | 蜂毒明肽 Apamin | 24345-16-2 | 1mg | 2500元 |