2378853-66-6
中文名称
化合物 CCT373566
英文名称
[1,4]Oxazepino[2,3-c]quinolin-6(7H)-one, 10-[[5-chloro-2-[(3R,5S)-3-hydroxy-5-methyl-1-piperidinyl]-4-pyrimidinyl]amino]-2-cyclopropyl-3,3-difluoro-1,2,3,4-tetrahydro-7-methyl-, (2S)-
CAS
2378853-66-6
分子式
C26H29ClF2N6O3
分子量
547
MOL 文件
2378853-66-6.mol
结构式
基本信息
中文别名
化合物 CCT373566
英文别名
CCT373566
[1,4]Oxazepino[2,3-c]quinolin-6(7H)-one, 10-[[5-chloro-2-[(3R,5S)-3-hydroxy-5-methyl-1-piperidinyl]-4-pyrimidinyl]amino]-2-cyclopropyl-3,3-difluoro-1,2,3,4-tetrahydro-7-methyl-, (2S)-
[1,4]Oxazepino[2,3-c]quinolin-6(7H)-one, 10-[[5-chloro-2-[(3R,5S)-3-hydroxy-5-methyl-1-piperidinyl]-4-pyrimidinyl]amino]-2-cyclopropyl-3,3-difluoro-1,2,3,4-tetrahydro-7-methyl-, (2S)-
物理化学性质
| 沸点 | 704.8±70.0 °C(Predicted) |
| 密度 | 1.50±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 14.34±0.40(Predicted) |
| 形态 | Solid |
| 颜色 | Light yellow to yellow |
应用领域
用途一
CCT373566 is a highly potent BCL6 degrader (IC50 =0.7 nM) suitable for sustained depletion of BCL6 in vivo. CCT373566 showed modest in vivo efficacy in a lymphoma xenograft mouse model following oral dosing. The transcriptional repressor BCL6 is an oncogenic driver found to be deregulated in lymphoid malignancies.