2220141-46-6
英文名称
VU6007477
CAS
2220141-46-6
分子式
C24H26N6O2
分子量
430.5
MOL 文件
2220141-46-6.mol
结构式
基本信息
英文别名
VU6007477
应用领域
用途一
VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat braiplasma Kp = 0.28, Kp,uu = 0.32; mouse Kp = 0.16, Kp,uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures).