208109-38-0
中文名称
F 13714
英文名称
Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-
CAS
208109-38-0
分子式
C21H25ClF2N4O
分子量
422.9
MOL 文件
208109-38-0.mol
结构式
基本信息
中文别名
F 13714
英文别名
Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-
应用领域
用途一
F13714 is a Serotonin 5-HT1A Receptor Agonist. F13714 shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress. F13714 has a high affinity (0.1 nM) and selectivity for 5-HT(1A) receptors. In vitro (18)F-F13714 binding in rats was consistent with the known 5-HT(1A) receptors distribution (hippocampus and cortical areas) and was particularly high in the dorsal raphe. In vitro binding of (18)F-F13714 was blocked in a dose-dependent fashion by WAY100635, the prototypical 5-HT(1A) antagonist, and by the endogenous agonist, serotonin (5-HT). Addition of Gpp(NH)p also inhibited in vitro (18)F-F13714 binding, consistent with a preferential binding of the compound to G-protein-coupled receptors. Ex vivo tissue measurements in rat revealed an absence of brain radioactive metabolites.
供应商信息 更多
合肥孚亚生物技术有限公司
联系电话：
18096409024
产品介绍：
英文名称：F 13714/F 14679/(3-Chloro-4-fluorophenyl)(4-fluoro-4-((((5-methyl-6-(methylamino)pyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone
CAS：208109-38-0
纯度：95% HPLC
包装信息：100MG;500MG
上海毕得医药科技股份有限公司
联系电话：
400-1647117 13681763483
产品介绍：
中文名称：(3-氯-4-氟苯基)(4-氟-4-((((5-甲基-6-(甲基氨基)吡啶-2-基)甲基)氨基)甲基)哌啶-1-基)甲酮
英文名称：(3-Chloro-4-fluorophenyl)(4-fluoro-4-((((5-methyl-6-(methylamino)pyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone
CAS：208109-38-0
纯度：98%
包装信息：1mg;5mg;10mg;25mg;50mg;100mg
备注：BD01431981
TargetMol中国（陶术生物）
联系电话：
4008200310
产品介绍：
中文名称：化合物 F 14679
英文名称：F 14679
CAS：208109-38-0
纯度：99.09%
包装信息：50mg/RMB 11531;25mg/RMB 8870;100mg/RMB 17297