190602-72-3
中文名称
化合物 T28908
英文名称
3H-Imidazo[4,5-c]pyridine-4-carboxylic acid, 5-acetyl-4,5,6,7-tetrahydro-2-propyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, [[(1-ethylpropoxy)carbonyl]oxy]methyl ester, hydrochloride (1:1)
CAS
190602-72-3
分子式
C33H40ClN7O6
分子量
666.18
MOL 文件
190602-72-3.mol
结构式
基本信息
中文别名
化合物 T28908
英文别名
TA-606 free
3H-Imidazo[4,5-c]pyridine-4-carboxylic acid, 5-acetyl-4,5,6,7-tetrahydro-2-propyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, [[(1-ethylpropoxy)carbonyl]oxy]methyl ester, hydrochloride (1:1)
3H-Imidazo[4,5-c]pyridine-4-carboxylic acid, 5-acetyl-4,5,6,7-tetrahydro-2-propyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, [[(1-ethylpropoxy)carbonyl]oxy]methyl ester, hydrochloride (1:1)
应用领域
用途一
TA-606, also known as TA-606 free, is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. TA-606 was immediately converted to its active form, 606A, after oral administration, and it demonstrated potent inhibition of the Ang II-induced pressor response in conscious normotensive dogs. It also had a potent hypotensive effect in conscious 2K,1C-renal hypertensive dogs. These effects of TA-606 were 32 and 30 times more potent than those of losartan, respectively. In addition, EXP3174, an active metabolite of losartan, but not 606A showed an orthostatic hypotensive effect in the rat tilting model.