189198-30-9
基本信息
7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸
pactimibe
2-[7-(2,2-dimethylpropanoylamino)-4,6-dimethyl-1-octyl-2,3-dihydroindo l-5-yl]acetic acid
7-[(2,2-Dimethyl-1-oxopropyl)amino]-2,3-dihydro-4,6-dimethyl-1-octyl-1H-indole-5-acetic acid
物理化学性质
| 沸点 | 604.4±55.0 °C(Predicted) |
| 密度 | 1.071 |
| 储存条件 | 4°C, away from moisture |
| 溶解度 | DMSO: 200 mg/mL (480.08 mM) |
| 酸度系数(pKa) | 4.00±0.10(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-100401 | 7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸 Pactimibe | 189198-30-9 | 1 mg | 1650元 |
| 2026/09/15 | HY-100401 | 7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸 Pactimibe | 189198-30-9 | 5mg | 3600元 |
| 2026/09/15 | HY-100401 | 7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸 Pactimibe | 189198-30-9 | 10 mM * 1 mL in DMSO | 3960元 |
常见问题列表
|
ACAT1 4.9 μM (IC 50 ) |
ACAT2 3.0 μM (IC 50 ) |
ACAT 2 μM (IC 50 , in the liver) |
ACAT 2.7 μM (IC 50 , in macrophages) |
ACAT 4.7 μM (IC 50 , in THP-1 cells) |
oleoyl-CoA 5.6 μM (Ki) |
cholesteryl ester formation 6.7 μM (IC 50 ) |
Pactimibe sulfate (CS-505) induces moderate ACAT inhibition in monocyte-derived macrophages, leading to the suppression of foam cell formation.
Pactimibe sulfate (CS-505; 60 and 200 mg/kg/day; oral gavage; twice a day; 12 weeks) induces an inhibition for ACAT-1 and ACAT-2, causing a reduction of plasma cholesterol but no influence on macrophage- or collagen-positive areas.
| Animal Model: | Male C57BL/6J ApoE −/− mice aged 8-week-old |
| Dosage: | 60 and 200 mg/kg/day |
| Administration: | Oral gavage; twice a day; 12 weeks |
| Result: | Decreased plasma cholesterol levels by 39% and 74% at the administration of 60 and 200 mg/kg/day. |