182004-65-5
基本信息
KB-R7943 甲磺酸盐
KB-R7943 甲磺酰酸盐
S-[4-[(4-硝基苄基)氧代]苯乙基]异硫脲甲磺酸盐
S-[4-[(4-硝基苄基)氧代]苯乙基]异硫脲甲磺酸盐
S-[4-[(4-硝基苄基)氧代]苯乙基]异硫脲甲磺酸盐(易制爆,甄准不供应)
S-[4-[(4-NITROBENZYL)OXY]PHENETHYL]ISOTHIOUREA METHANESULFONATE S-[4-[(4-硝基苄基)氧代]苯乙基]异硫脲甲磺酸盐
KB-R7943
KB-R7943 MESYLATE
KB-R7943 - CAS 182004-65-5 - Calbiochem
2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate
4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate
S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate >
2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA, METHANE SULFONATE
S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate
物理化学性质
| 熔点 | >214°C (dec.) |
| 储存条件 | Inert atmosphere,2-8°C |
| 储存条件 | Store at RT |
| 溶解度 | 溶于DMSO（高达50mg/ml）。 |
| 形态 | 白色结晶固体 |
| 颜色 | Tan |
| 水溶解性 | water: 4mg/mL DMSO: 40mg/mL |
| 稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
| InChI | InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4) |
| InChIKey | WGIKEBHIKKWJLG-UHFFFAOYSA-N |
| SMILES | S(O)(=O)(=O)C.C(C1C=CC(N(=O)=O)=CC=1)OC1C=CC(CCSC(N)=N)=CC=1 |
安全数据
| 危险性符号(GHS) |  GHS09 |
| 警示词 | 警告 |
| 危险性描述 | H400 |
| 防范说明 | P273-P391-P501 |
| 海关编码 | 2930.90.2900 |
KB-R7943 甲磺酰酸盐价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-15415 | KB-R7943 甲磺酰酸盐 KB-R7943 mesylate | 182004-65-5 | 5 mg | 493元 |
| 2025/05/22 | HY-15415 | KB-R7943 甲磺酰酸盐 KB-R7943 mesylate | 182004-65-5 | 10mg | 790元 |
| 2025/05/22 | HY-15415 | KB-R7943 甲磺酰酸盐 KB-R7943 mesylate | 182004-65-5 | 10mM * 1mLin DMSO | 869元 |
常见问题列表
IC50: 5.7±2.1 µM (Na + /Ca 2+ exchanger)
KB-R7943 mesylate blocks NMDAR-mediated ion currents, and inhibits NMDA-induced increase in cytosolic Ca 2+ with IC 50 =13.4±3.6 µM but accelerates calcium deregulation and mitochondrial depolarization in glutamate-treated neurons. KB-R7943 depolarizes mitochondria in a Ca 2+ -independent manner. KB-R7943 inhibits 2,4-dinitrophenol-stimulated respiration of cultured neurons with IC 50 =11.4±2.4 µM. In addition to NCX rev , KB-R7943 dose-dependently and reversibly blocked ion currents elicited by NMDA. KB-R7943 dose-dependently inhibits NMDA-induced increases in [Ca 2+ ] c with IC 50 =13.4±3.6 µM confirming the inhibition of NMDA receptors observed in electrophysiological experiments. wt RyR1-HEK 293 pretreated with KB-R7943 (10 μM, 10 min) dissolved in the bulk perfusion exhibited significantly attenuated responses to caffeine. In this regard, KB-R7943 produced more pronounced inhibition of caffeine-induced Ca 2+ release elicited by 1 mM compared with 0.5 and 0.75 mM (60 versus 58 versus 37%, p<0.05, respectively). KB-R7943 inhibits both I hERG and native I Kr rapidly on membrane depolarization with IC 50 values of ~89 and ~120 nM, respectively, for current tails at −40 mV following depolarizing voltage commands to +20 mV. I hERG inhibition by KB-R7943 exhibits both time- and voltage-dependence but shows no preference for inactivated over activated channels.