17974-57-1
基本信息
β-Apo-13-carotenone
3,5,7-Octatrien-2-one, 6-methyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (3E,5E,7E)-
物理化学性质
| 沸点 | 120 °C(Press: 0.0004 Torr) |
| 密度 | 0.945±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | DMSO : 33.33 mg/mL (128.99 mM);Water : < 0.1 mg/mL (insoluble) |
| 形态 | Oil |
| 颜色 | Light yellow to yellow |
β-Apo-13-carotenone价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-101953 | β-Apo-13-carotenone | 17974-57-1 | 1 mg | 1818元 |
| 2025/02/08 | HY-101953 | β-Apo-13-carotenone β-Apo-13-carotenone | 17974-57-1 | 5mg | 4000元 |
| 2024/08/19 | HY-101953 | β-Apo-13-carotenone β-Apo-13-carotenone | 17974-57-1 | 10mg | 6800元 |
常见问题列表
β-apo-13-Carotenone is identified as enzymatic cleavage products of β-carotene in homogenates of intestinal mucosa of rat. β-apo-13-carotenone is found to antagonize the activation of RXRα by 9-cis-retinoic acid and is effective at concentrations as low as 1nM. Molecular modeling studies reveal that β-apo-13-carotenone makes molecular interactions like an antagonist of RXRα. β-apo-13-carotenone competes for 9cRA binding to RXRα with an affinity (7–8 nM) identical to 9cRA itself. β-apo-13-carotenone antagonizes 9cRA activation of full-length hRXRα with a similar efficiency as the known antagonist UVI3003. β-apo-13-carotenone induces formation of the RXRα transcriptionally silent tetramer but does not inhibit coactivator recruitment to the isolated LBD. The uptake and/or metabolism of β-apo-13-carotenone does not allow for accumulation of these β-carotene metabolites in cells. 3T3-L1 adipocyte marker gene expression is induced by β-apo-carotenoid treatment.