1620837-70-8
英文名称
L-Valinamide, N-[[[4-[[N-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]ethoxy]acetyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
CAS
1620837-70-8
分子式
C71H104N12O18
分子量
1413.66
结构式
基本信息
英文别名
Bi-Mc-VC-PAB-MMAE
L-Valinamide, N-[[[4-[[N-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]ethoxy]acetyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]...
L-Valinamide, N-[[[4-[[N-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]ethoxy]acetyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
L-Valinamide, N-[[[4-[[N-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]ethoxy]acetyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]...
L-Valinamide, N-[[[4-[[N-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]ethoxy]acetyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
物理化学性质
| 沸点 | 1414.1±65.0 °C(Predicted) |
| 密度 | 1.247±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 13.07±0.46(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
常见问题列表
概述
Bi-Mc-VC-PAB-MMAE 由ADC linker (Fmoc-Val-Cit-PAB) 和 MMAE 组成，MMAE 是一种有效的 (tubulin) 抑制剂。Bi-Mc-VC-PAB-MMAE 可用于偶联抗体。