1610562-74-7
中文名称
BMS-986118
英文名称
BMS-986118
CAS
1610562-74-7
分子式
C25H28ClF3N4O4
分子量
540.96
MOL 文件
1610562-74-7.mol
结构式
物理化学性质
| 沸点 | 633.1±65.0 °C(Predicted) |
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 4.36±0.10(Predicted) |
应用领域
用途一
BMS-986118 is a GPR40 full agonist. GPR40 is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been_x000D_
a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial agonists elicits insulin secretion only in the presence of elevated blood glucose levels, minimizing the risk of hypoglycemia.