1581764-31-9
中文名称
化合物 EBI-907
英文名称
EBI-907
CAS
1581764-31-9
分子式
C23H21ClF2N4O3S
分子量
506.95
MOL 文件
1581764-31-9.mol
结构式
物理化学性质
| 沸点 | 685.6±65.0 °C(Predicted) |
| 密度 | 1.58±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 7.09±0.10(Predicted) |
应用领域
用途一
EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM). EBI-907 also exhibits high potency in selectively inhibiting the proliferation of BRAF (V600E)-dependent cell lines (A375 and Colo205) and cellular Erk phosporylation, with superior activity to Vemurafenib. EBI-907, displaying potent activity against a number of important oncogenic kinases including BRK, FGFR1, c-Kit, and PDGFRb.