14984-68-0
基本信息
盐酸氯哌丁
盐酸氯哌斯汀
4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE
CHLOPERASTINE HYDROCHLORIDE
CLOPERASTINE HCL
CLOPERASTINE HYDROCHLORIDE
1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)piperidinehydrochloride
1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride
1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato
2-piperidinoethylp-chlorobenzhydryletherhydrochloride
cloperastinacloridrato
ht11
hustazol
4-chlorobenzhydryl 2-(1-piperidyl)ethyl ether
物理化学性质
| 熔点 | 147.9° |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | neat |
| 颜色 | 白色至灰白色 |
| Merck | 14,2395 |
| CAS 数据库 | 14984-68-0(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302 |
| 防范说明 | P501-P270-P264-P301+P312+P330 |
| 危险品标志 | Xn |
| 危险类别码 | R22 |
| 安全说明 | S36 |
| WGK Germany | 3 |
| RTECS号 | TM6491500 |
| 海关编码 | 2933.39.9200 |
知名试剂公司产品信息
盐酸氯哌斯丁价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | C3038 | 氯哌斯汀盐酸盐 Cloperastine Hydrochloride | 14984-68-0 | 5g | 290元 |
| 2024/11/08 | HY-B2133 | 盐酸氯哌斯丁 Cloperastine hydrochloride | 14984-68-0 | 500mg | 300元 |
| 2024/11/08 | HY-B2133 | 盐酸氯哌斯丁 Cloperastine hydrochloride | 14984-68-0 | 10mM * 1mLin DMSO | 330元 |
常见问题列表
27 nM (K + currents)
Cloperastine inhibits the hERG K
+
currents in a concentrationdependent manner with an IC
50
value of 27 nM.
Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic
action potential (MAP) duration without affecting PR interval or QRS width.
Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD
50
in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.