143691-37-6
中文名称
GYKI 53405
英文名称
GYKI 53405
CAS
143691-37-6
分子式
C19H19N3O3
分子量
337.37
MOL 文件
143691-37-6.mol
结构式
基本信息
中文别名
化合物 T32034
英文别名
LY 293606
GYKI 53405
1-[5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
Ethanone, 1-[5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-7-yl]-
GYKI 53405
1-[5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
Ethanone, 1-[5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-7-yl]-
安全数据
危险性符号(GHS) | GHS09,GHS06 |
警示词 | 危险 |
危险性描述 | H410-H301 |
防范说明 | P264-P270-P301+P310-P321-P330-P405-P501-P273-P391-P501 |
应用领域
用途一
GYKI-53405, also known as LY 293606, is a noncompetitive AMPA receptor antagonist. GYKI-53405 binds specifically to Xenopus brain membranes with KD and Bmax values of 4.5 microM and 35 pmol mg-1 protein respectively. Binding is increased in the presence of Mg2+ and is unaffected by AMPA or kainate.