140944-30-5

Silperisone, also known as RGH-5002; SILA-336, a sodium channel protein type 2 alpha channel blocker potentially for the treatment of spasticity. Silperisone is a tolperisone like organosilicon compound with centrally acting muscle relaxant properties. Silperisone might be a useful antispastic drug. However, findings in chronic animal toxicity studies led to the discontinuation of silperisone's development.

Silperisone hydrochloride 是一种类似于 tolperisone 的有机硅化合物，具有中枢作用的肌肉松弛剂特性。Silperisone (hydrochloride) 是钠通道 (sodium channel) 蛋白 2 型 α 通道阻滞剂，阻断细胞中的钠和钙通道，使肌肉细胞的兴奋度和收缩度降低，降低外周张力，充当肌肉松弛剂和外周血管扩张剂。Silperisone (hydrochloride) 可用于对脊髓损伤引起的复发性疼痛性肌阵挛，脑血管病引起的异常高肌张力，肌张力症状，锥体紧张综合征，多发性硬化症肌痉挛和脊髓炎的研究。