1354041-91-0
中文名称
化合物 T32242
英文名称
IWP-051
CAS
1354041-91-0
分子式
C17H11F2N5O2
分子量
355.3
MOL 文件
1354041-91-0.mol
结构式
应用领域
用途一
IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.