133406-29-8
基本信息
6-氯-2-(三氯甲基)-4H-苯并吡喃-4-酮
ST034307 >=98% (HPLC)
ST034307
ST-034307
ST 034307
6-chloro-2-(trichloromethyl)-4H-chromen-4-one
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-
物理化学性质
| 沸点 | 329.1±42.0 °C(Predicted) |
| 密度 | 1.674±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 可溶于 DMSO（高达 30 mg/ml）或乙醇（高达 6 mg/ml） |
| 形态 | 固体 |
| 颜色 | 黄色 |
| 稳定性 | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302 |
| 防范说明 | P280-P305+P351+P338 |
133406-29-8价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-101279 | 133406-29-8 ST034307 | 133406-29-8 | 5mg | 770元 |
| 2024/11/08 | HY-101279 | 133406-29-8 ST034307 | 133406-29-8 | 10mM * 1mLin DMSO | 847元 |
| 2024/11/08 | HY-101279 | 133406-29-8 ST034307 | 133406-29-8 | 10mg | 1200元 |
常见问题列表
IC50: 2.3 μM (AC1)
ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca 2+ /calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1.
ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E 50 ) value for analgesia of 0.28 μg in the mouse pain model.