131614-02-3
中文名称
E 6123
英文名称
E 6123
CAS
131614-02-3
分子式
C23H22ClN5OS
分子量
451.972
MOL 文件
131614-02-3.mol
结构式
基本信息
中文别名
化合物 T15188
英文别名
E 6123
E ?6123,E?6123
JEQVYSUCZLYBRQ-LBPRGKRZSA-N
4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 6-(2-chlorophenyl)-9-(cyclopropylcarbonyl)-7,8,9,10-tetrahydro-1,4-diMethyl-, (4S)- (9CI)
E ?6123,E?6123
JEQVYSUCZLYBRQ-LBPRGKRZSA-N
4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 6-(2-chlorophenyl)-9-(cyclopropylcarbonyl)-7,8,9,10-tetrahydro-1,4-diMethyl-, (4S)- (9CI)
物理化学性质
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
常见问题列表
生物活性
E-6123 是一种血小板活化因子 (PAF) 受体拮抗剂。
靶点
PAF
体外研究
E-6123 (E6123) partially inhibits the Thapsigargin-induced increase in the levels of interleukin-6 mRNA and interleukin-6 protein. To clarify the role of the concurrently produced cell-associated PAF in the thapsigargin-induced increase in the interleukin-6 mRNA level and interleukin-6 production, the effects of the PAF receptor antagonist E-6123 are examined. E-6123 at 1 and 10 μM partially inhibits the Thapsigargin (46.1 nM)-induced increase in the interleukin-6 mRNA level at 4 h and interleukin-6 production at 8 h.