129735-01-9
中文名称
RP-8-CPT-CAMPS
英文名称
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
CAS
129735-01-9
分子式
C16H15ClN5O5PS2
分子量
487.88
MOL 文件
129735-01-9.mol
结构式
基本信息
中文别名
英文别名
RP-8-CPT-CAMPS
RP-8-CPT-CAMPS SODIUM SALT
8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER
Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate]
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi
RP-8-CPT-CAMPS SODIUM SALT
8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER
Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate]
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi
物理化学性质
| 储存条件 | −20°C |
| 形态 | solid |
| 生物来源 | synthetic (organic) |
安全数据
| WGK Germany | 3 |
常见问题列表
生物活性
Rp-8-CPT-cAMPS，一种 cAMP 类似物，是 cAMP 诱导的依赖 cAMP 的 PKA I 和 PKA II 活化的有效和竞争性的拮抗剂。Rp-8-CPT-cAMPS 优先选择 RI 的位点 A 与 RII 的位点 B。
靶点
PKA
体外研究
Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol.
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP.
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP.
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings.