127910-31-0
![127910-31-0 结构式](https://www.chemicalbook.com/CAS/GIF/127910-31-0.gif)
基本信息
CGP 37849
CGP-37849
CGP37849
dl-2-amino-4-methyl-5-phosphono-3-*pentenoic acid
(E)-2-Amino-4-methyl-5-phosphonopent-3-enoic acid
(3E)-2-Amino-4-methyl-5-phosphono-3-pentanoic acid
(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-
(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
物理化学性质
沸点 | 523.1±60.0 °C(Predicted) |
密度 | 1.506±0.06 g/cm3(Predicted) |
储存条件 | Desiccate at +4°C |
溶解度 | 在水中的溶解度为≥2mg/mL(加热) |
酸度系数(pKa) | 1.83±0.10(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
安全数据
危险性符号(GHS) | ![]() GHS07 |
警示词 | 警告 |
危险性描述 | H315-H319-H335 |
防范说明 | P261-P305+P351+P338 |
危险品标志 | Xi |
危险类别码 | 36/37/38 |
安全说明 | 26-36 |
WGK Germany | 3 |
常见问题列表
In the hippocampal slice in vitro, CGP 37849 selectively and reversibly antagonizes NMDA-evoked increases in CA1 pyramidal cell firing rate. In slices bathed in medium containing low Mg 2+ levels, concentrations of CGP 37849 up to 10 μM suppresses burst firing evoked in CA1 neurones by stimulation of Schaffer collateral-commissural fibres without affecting the magnitude of the initial population spike.
CGP 37849 potently (
K
i
of 220 nM) and competitively inhibits NMDA-sensitive l-[
3
H]-glutamate binding to postsynaptic density (PSD) fractins from rat brain. CGP 37849 inhibits the binding of the selective NMDA receptor antagonist, [
3
H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP), with a
K
i
of 35 nM.
In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurones induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate.
Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an
ED
50
of 21 mg/kg.