1254979-66-2
中文名称
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1-piperazinyl]methyl]-8-(trifluoromethyl)-
英文名称
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1-piperazinyl]methyl]-8-(trifluoromethyl)-
CAS
1254979-66-2
分子式
C22H22F5N5
分子量
451.44
MOL 文件
1254979-66-2.mol
结构式
基本信息
中文别名
化合物 T27686
英文别名
JNJ46356479
JNJ-46356479
JNJ 46356479
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1-piperazinyl]methyl]-8-(trifluoromethyl)-
JNJ-46356479
JNJ 46356479
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1-piperazinyl]methyl]-8-(trifluoromethyl)-
应用领域
用途一
JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256. JNJ-46356479 is in vivo active, sw-EEG at 3mg/kg, p.o. JNJ-46356479 represents a more balanced profile that offers a significant improvement on the druglike attributes compared to previously reported leads.
常见问题列表
概述
JNJ-46356479 是一种选择性的口服生物可利用的 mGlu2 receptor阳性变构调节剂，EC0 值 为 78 nM。JNJ-46356479 在体内有活性。