Uses
3-OH-Kynurenamine is a lateral metabolite in Tryptophan (HY-N0623) metabolism. 3-OH-Kynurenamine induces a concentration-dependent AhR activation, around 6.5 times higher than L-kynurenine (HY-104026). 3-OH-Kynurenamine confers immunosuppressive properties on dendritic cells (DCs). 3-OH-Kynurenamine can be used for psoriasis research[1].
Definition
ChEBI: 3-hydroxykynurenamine is a hydroxykynurenamine that is kynurenamine carrying a hydroxy group at position 3. It is a metabolite of tryptophan that exhibits antiinflammatory and immunomodulatory properties. It has a role as an anti-inflammatory agent, an immunomodulator and a human metabolite. It is a member of phenols and a hydroxykynurenamine.
in vivo
3-OH-Kynurenamine (50 mg/kg, ip, daily, for 7 days) decreases clinical and histological manifestation of psoriasis, and attenuates nephrotoxic nephritis (NTN) in mice[1].
References
[1] Laura SANTAMBROGIO. Immunoregulatory role of 3-oh-kynurenamine and uses thereof. Patent, WO2019178013A1.
