985-13-7

Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease[1][2][3].

Poison by intravenous route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic vapors of NOx, HCl, and Clí

[1] Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5. PMID:1658607
[2] Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6. DOI:10.1016/0006-2952(94)90399-9
[3] Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5. DOI:10.1248/bpb.24.103
[4] Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107(4):227-9. DOI:10.1001/archotol.1981.00790400029006
[5] Lacroix P, et al. [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French. PMID:962426
[6] Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40. DOI:10.1248/bpb.24.838